Avram Hershko Edit Profile
biochemisteducator
Avram Hershko, Hungarian, Israeli biochemist, educator. Achievements include discovery of the significance of the body's mechanism for destroying proteins which plays a key role in immunity, inflammation and cancer; discovery of ubiquitin-mediated protein degradation. Member of National Academy of Sciences (foreign associate), American Academy Arts & Sciences (foreign honorary), European Molecular Biology Organization.
Background
Hershko, Avram was born on December 31, in Karcag, Hungary. Arrived in Israel, Son of Moshe and Shoshana Margit (Manci) Hershko.
Education
Doctor of Medicine, Hebrew University Hadassah Medical School, Jerusalem, Doctor of Philosophy, Hebrew University Hadassah Medical School, Jerusalem,
Career
Postdoctoral fellow University California, San Francisco, — Associate professor Technion-Israel Institute of Technology, Haifa, —, professor, since , distinguished professor biochemistry, Rappaport Faculty Medicine, since Visiting researcher Fox Chase Cancer Center, Philadelphia, —
With Israel Defense Forces,
Achievements
Avram H
Avram Hershko
Israeli biochemist Date of Birth:
Country: Israel
Content:- Avram Hershko: A Nobel Prize-Winning Biochemist
- Research and Discoveries
- Affiliations and Honors
- Legacy
Avram Hershko: A Nobel Prize-Winning Biochemist
Early Life and EducationAvram Hershko, a distinguished Israeli biochemist, was born on December 31, , in Karcag, Hungary. His parents, Moshe and Margit Hershko, nurtured his passion for learning. In , the family faced adversity during World War II, being forced into ghettos and labor camps. Despite these challenges, Avram Hershko emerged from the war with a resilient spirit.
After immigrating to Israel in , Hershko dedicated himself to studying medicine at the Hadassah Faculty of Medicine in Jerusalem. He earned his Master's degree in and his Doctorate in , embarking on a distinguished academic career.
Research and Discoveries
Hershko's pioneering research focused on cellular degradation. Together with Aaron Ciechanover and Irwin Rose, he elucidated the role of ubiquitin in the proteasome pathway, a crucial process for maintaining cell homeostasis. This groundbreaking discovery earned them the Nobel Prize in Chemistry in
Her
Avram Hershko
Avram Hershko is an Israeli biochemist and winner of the Nobel Prize for Chemistry.
Hershko (born December 31, ) was born as Hersko Ferenc in Karcag, Hungary. In , Hershko and his family emigrated from Hungary to Israel, where he adopted the name Avram. Hershko received his M.D. and Ph.D. from the Hadassah Medical School of the Hebrew University. In , Hershko worked as a physician in the Israel Defense Forces.
In , Hershko was a postdoctoral fellow with the late Dr. Gordon Tomkins at the University of California, San Francisco.
In , Hershko was awarded the Weizmann Prize for Sciences, an honor given to top Israeli scientists. In , he won the Israeli Prize for his contributions to Israeli society through biochemistry and medicine.
In , Hershko was awarded the Nobel Prize in Chemistry “for the discovery of ubiquitin-mediated protein degradation.” He shared the award with fellow Israeli Aaron Ciechanover as well as American biologist Irwin Rose.
In , Hershko and Ciechanover were jointly voted as the 31st-greatest Israelis of all time in an online poll.
Sources:Albert and Mary Lasker Foundation; ; Wikipedia
Distinguished Professor Avram Hershko, renowned worldwide for his research in biochemistry, biophysics, and molecular biology, shared the Nobel Prize in Chemistry with Distinguished Technion Professor Aaron Ciechanover and the late Professor Irwin Rose of the University of California, Irvine, for finding and defining ubiquitin-mediated protein degradation. Their prize came two decades after the momentous discovery.
In , while most researchers were focused on how living beings build up proteins, Professor Hershko and his team were examining the flipside of the process — how the body rids itself of proteins that are no longer useful. His research resulted in the Nobel Prize- discovery of the crucial role played by the protein ubiquitin in targeting abnormal proteins for destruction and escorting them to something akin to a cellular waste-disposal unit. The breakthrough has led to the drug Velcade, used in the treatment of multiple myeloma, and continues to yield insights into the prevention and treatment of cancer, leukemia, cystic fibrosis, and neurodegenerative conditions such as Alzheimer’s and Parkinson’s.
Prof. Hershko was born in Hungary and emigrated with his family to Is
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